SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis

SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis

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Abstract Background Astrocytoma is a common tumor type in primary central nervous system and has a high death rate around the world.Aberrant expression of long non-coding RNAs (lncRNAs) has been introduced by emerging studies to result in the development of diverse cancers.Methods RT-qPCR examined the expression of SNHG17, miR-876-5p and ERLIN2, and western blot evaluated ERLIN2 protein level.

RNA pull down and luciferase reporter assays illustrated sheepshead bay boats the relationships between SNHG17 and its downstream molecules.Results SNHG17 was up-regulated in astrocytoma cells.Moreover, SNHG17 silence could repress the proliferation, migration and invasion of astrocytoma cells.

Besides, miR-876-5p was selected out as a downstream molecule of SNHG17 in astrocytoma.ERLIN2 was determined to be targeted by miR-876-5p.ERLIN2 mRNA and protein levels were lessened by miR-876-5p overexpression and SNHG17 silence.

Additionally, miR-876-5p overexpression decelerated the biological processes of astrocytoma cells, so did ERLIN2 knockdown.More importantly, the impacts of SNHG17 down-regulation on the malignant behaviors of astrocytoma cells were counteracted by overexpressed ERLIN2 or inhibited miR-876-5p.Conclusions SNHG17 could induce the progression of astrocytoma by sponging tokidoki hello kitty blind box miR-876-5p to elevate the expression of ERLIN2.

This study indicated that SNHG17 has a high potential to be a therapeutic target for astrocytoma.